10-1-5　ⓔ文献

  1. Lynch TJ, Bell DW, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non–small–cell lung cancer to gefitinib. N Engl J Med, 2004; 350: 2129–2139.

  2. Paez JG, Jänne PA, et al: EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science, 2004; 304: 1497–1500.

  3. Kohno T, Nakaoku T, et al: Beyond ALK–RET, ROS1 and other oncogene fusions in lung cancer. Transl Lung Cancer Res, 2015; 4: 156–164.

  4. The ICGC/TCGA Pan–Cancer Analysis of Whole Genomes Consortium: Pan–cancer analysis of whole genomes. Nature, 2020; 578, 82–93.

  5. Allen RJ, Guillen–Guio B, et al: Genome–Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med, 2020; 201: 564–574.

  6. Sakornsakolpat P, Prokopenko D, et al: Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell–type and phenotype associations. Nat Genet, 2019; 51: 494–505.

  7. Demenais F, Margaritte–Jeannin P, et al: Multiancestry association study identifies new asthma risk loci that colocalize with immune–cell enhancer marks. Nat Genet, 2018; 50: 42–53.

  8. Montoro DT, Haber AL, et al: A revised airway epithelial hierarchy includes CFTR–expressing ionocytes. Nature, 2018; 560: 319–324.

  9. Plasschaert LW, Žilionis R, et al: A single–cell atlas of the airway epithelium reveals the CFTR–rich pulmonary ionocyte. Nature, 2018; 560: 377–381.

  10. Nabhan AN, Brownfield DG, et al: Single–cell Wnt signaling niches maintain stemness of alveolar type 2 cells. Science, 2018; 359: 1118–1123.

  11. Takahashi K, Yamanaka S: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell, 2006; 126: 663–676.

  12. Wong AP, Bear CE, et al: Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein. Nat Biotechnol, 2012; 30: 876–882.

  13. Suzuki T1, Mayhew C, et al: Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis. Am J Respir Crit Care Med, 2014; 189: 183–193.

  14. Yamamoto Y, Gotoh S, et al: Long–term expansion of alveolar stem cells derived from human iPS cells in organoids. Nat Methods, 2017; 14: 1097–1106.

  15. Mori M, Furuhashi K, et al: Generation of functional lungs via conditional blastocyst complementation using pluripotent stem cells. Nat Med, 2019; 25: 1691–1698.