3-6-4　ⓔ文献

  1. McCay CM, Crowell MF: Prolonging the life span. The Scientific Monthly, 1934; 39: 405–414.

  2. Blackburn EH, Epel ES, et al: J. Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection. Science, 2015; 350: 1193–1198.

  3. Adler AS, Sinha S, et al: Motif module map reveals enforcement of aging by continual NF–kappaB activity. Genes Dev, 2007; 21:3244–3257.

  4. Coppé JP, Patil CK, et al: Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol, 2008; 6: 2853–2868.

  5. Ridker PM, MacFadyen JG, et al: Effect of interleukin–1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double–blind, placebo-controlled trial. Lancet, 2017; 390: 1833–1842.

  6. Baker DJ, Wijshake T, et al: Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature, 2011; 479: 232–236.

  7. Chang J, Wang Y, et al: Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice. Nat Med, 2016; 22: 78–83.

  8. Tsukada M, Ohsumi Y: Isolation and characterization of autophagy–defective mutants of Saccharomyces cerevisiae. FEBS Lett, 1993; 333: 169–174.