ⓔノート18-6-1　ドパミンの低下

　1960年にEhringerとHornykiewiczらがPD患者脳でドパミンの低下を報告した¹⁾．同年大阪大学の佐野勇らも，PD患者脳でドパミンの低下を発表²⁾したが，日本語のため広く知られていない．

〔望月秀樹〕

■文献

1. Ehringer H, Hornykiewicz O: Distribution of noradrena–line and dopamine (3–hydroxytyramine) in human brain: Their behaviour in extrapyramidal system diseases. Klin Wochenschr, 1960; 38: 1236–1239. (Re–published in English translation in Parkinsonism and Related Disorders, 1998; 4: 53–57.)

2. Sano H: Biochemistry of the extrapyramidal system: Shinkei Kennkyu No Shinpo, Advances in Neurological Sciences, 1960; 5: 42–48. (Re–published in English translation in Parkinsonism Relat Disord, 2000; 6: 3–6.)