ⓔノート18-6-7　強迫症状

　精神症状を呈する患者の半数に強迫症状を認めるといわれ，強迫症状としては確認，洗浄，整頓，溜め込み，過食などを認める1,2)．強迫症状に不合理感が乏しい場合も多く，常同行為に分類する解釈もある3)．認知機能障害を伴うことが多い4)．

　初発症状としててんかん発作を呈し5)，家族性に側頭葉てんかんをきたすこともある6)．

〔中村雅之〕

■文献

  1. Walterfang M, Evans A, et al: The neuropsychiatry of neuroacanthocytosis syndromes. Neurosci Biobehav Rev, 2011; 35: 1275–1283.

  2. Ichiba M, Nakamura M, et al: Clinical and molecular genetic assessment of a chorea–acanthocytosis pedigree. J Neurol Sci, 2007; 263: 124–132.

  3. Walker RH: Untangling the thorns: advances in the neuroacanthocytosis syndromes. J Mov Disord, 2015; 8: 41–54.

  4. Danek A, Jung HH, et al: Neuroacanthocytosis: new developments in a neglected group of dementing disorders. J Neurol Sci, 2005; 229-230: 171–186.

  5. Nishida Y, Nakamura M, et al: Novel pathogenic VPS13A gene mutations in Japanese patients with chorea–acanthocytosis. Neurol Genet, 2019; 5: e332.

  6. Al–Asmi A, Jansen AC, et al: Familial temporal lobe epilepsy as a presenting feature of choreoacanthocytosis. Epilepsia, 2005; 46: 1256–1263.